Demand for Rabbit Pyrogen Testing to Fall Significantly over the Next Eight Years

Pyrogen cause fever when inserted in the body. Post-administration of pyrogen it elicits a rise in temperature causing an unfamiliar sensation which is usually stressful. Pyrogen testing is commonly conducted to detect pathogenic contamination of medicinal products.  Further, pyrogen testing helps medical lab experts determine endotoxin substances in drugs during initial test prior to their launch in the market. Pharmaceutical companies over the years have developed advanced pyrogen testing techniques to obtain more accurate results.


Rise in the number of pharmaceutical and biotech companies across the globe and increasing awareness on hygiene and healthcare are two major factors driving the global market for pyrogen testing. Moreover, growing emphasis on prevention and effective treatment of prolonged diseases at the initial stage is also anticipated to influence the demand for pyrogen testing. Moreover, demand for pyrogen testing is high from biotechnology, pharmaceutical and medical devices industry. On the contrary, its use in food and cosmetic industry is expected to grow in the near future. In addition, pyrogen testing for developing vaccines, injections, and tablets is expected to collectively account for a healthy share of the overall market revenue.

Higher investments in development and research programs and approval of new drugs in the market are expected to sustain the pyrogen market growth globally. Other factors such as growing per capita healthcare expenditure, and favorable government initiatives are expected to further support the market growth. Growing trends of medical tourism in regions such Latin American and Asia Pacific coupled with the expansion of the healthcare sector in emerging economies in further expected to govern the global pyrogen testing market over the next eight years. On the other hand, fierce competition amongst the market players and minimum market opportunity for new entrants may inhibit the market growth in the coming years.

The Four Major Types of Pyrogen Testing Available in the Market are:

  • Recombinant factor C assay,
  • Limulus amebocyte lysate (LAL),
  • Monocyte activation assay (MAT),
  • Rabbit pyrogen test.

Amongst these, demand for limulus amebocyte lysate test is expected to remain highest in the coming years. This is largely due to the growing preference for animal-free detection tests. Moreover, the test is considered to be highly reliable for detection of pyrogens. In contrast, increasing protest and restrictions against animal testing is expected to negatively impact the demand for rabbit pyrogen test.


Pharmaceutical companies are seeking to develop quicker methods of testing. Currently, handful laboratory experiments are available for detecting viruses, bacteria and fungi contamination. Hence, the companies are actively focusing on developing advanced and quicker texting solutions that can deliver immediate results. Likewise, pharmaceutical companies are looking forward to developing more advanced and effective techniques of pyrogen testing.


According to a recent study conducted by Persistence Market Report (PMR), in 2015, the global market for pyrogen testing stood at US$ 538.8 Mn. By 2024 end, the market is expected to grow to US$ 1.37 billion in terms of value. By regional outlook, North America is anticipated to be the most lucrative market for global pyrogen testing over the next few years. This is primarily due to the healthy presence of leading players of the market in the region. Growing research and developmental activities and increasing awareness on healthcare amongst people is also expected to further sustain the market growth in North America. In addition, demand for limulus amebocyte lysate test (LAL) is expected to be relatively high than other test types in North America. Latin America and Asia Pacific are the two other regions expected to witness a healthy growth of the markets over the next eight years.

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