The global market for cell-free protein expression is anticipated to register 6% CAGR during 2016 to 2024 and reach a market value of US $268.4 million by 2024 end according to a study by Persistence Market Research (PMR). The future landscape of global cell-free protein expression market will be defined by novel approaches & development of cost-effective, fast and reliable methods for proteins production on an industrial scale. Factors such as increasing R&D outsourcing by biotechnological and pharmaceutical companies, sales drop of patent cliff resulting into increasing research intensity in pharmaceutical sector, declining R&D productivity and increasing bio-similar development expenditure are expected to drive the global cell-free protein expression market.
Establishment of Precipitating & Soluble Membrane Fragment Methods by Study of Mammalian Membrane Protein Production
Cell-free protein expression basically is the process of recombinant proteins production in cell lysates instead of cultured cells. Cell-free protein expression methods are expected to come forth as the standard procedures for oriented membrane protein preparation- crystallography, since they tackle ceaseless problems associated with cell-based recombinant expression methods pertaining to mammalian membrane proteins preparation. As per Scientific Reports 6, Article 30442, solution to four membrane proteins’ crystal structures, from unicellular alga or bacteria, has been obtained through samples prepared by cell-free protein synthesis.
This study on mammalian membrane protein production establishes the soluble and precipitating membrane fragment methods in which synthesis of membrane proteins takes course through Escherichia coli cell-free system including small & large membrane fragments with simultaneous integration of these fragments into lipid environments. Various mammalian membrane proteins such as γ-secretase subunits, human claudins and glucosylceramide synthase can be produced by applying precipitating membrane fragment method. While, substantial membrane proteins cab be produced by applying soluble membrane fragment method. As per this study, obtaining high quality crystals of complex human claudin-4 was successful by using enterotoxin.
Profacgen’s Announcement of Advancing its Facilities & Platforms for Thorough Feasibility Analysis
Profacgen, a New York-based biotech company, recently made an announcement about its plans on advancing its platforms & facilities in order to perform a thorough feasibility analysis prior to the initiation of every protein expression project deployed by it. Profacgen significantly focuses on cell-free expression & animal-free expression. Recombinant protein expression’s key success depends upon the appropriate protein expression system choice. Several factors must be considered including intended application, target protein property, cost and protein yield while choosing the system.
A comprehensive expression systems portfolio is provided by Profacgen’s services of custom recombinant proteins. System that are often used by Profacgen’s customers include yeast expression, bacteria expression, mammalian expression and insect/baculovirus expression. World-class protein biologists of Profacgen have extensive experience in the field of protein expression. Profacgen commits to provide more customer-friendly services by advancing their technology to these services.
Invenra Raises $3 Million for Antibodies Development
WI-based Invenra’s cell-free protein expression technology allows screening of thousands of full antibodies at a much faster rate than conventional cell-based methods used for searching therapeutic antibodies. Last year, Invenra announced raising $3 million for development of antibodies with and for drug makers. Some of this money, according to Mark Kubik, Invenra’s vice president for business development, will be applied for fulfilling its agreements made with drug companies which includes U.K.-based Oxford BioTherapeutics.
Cell-free protein expression is a convenient method for small amounts of protein generation used for several applications such as protein-nucleic acid interactions, protein-protein interactions, functional assays, toxicity screening and structural analysis. Providing quick and easy access to proteins of interest, cell-free protein expression remains stapled to collection of tools available for understanding cellular pathways & mechanisms, protein structure & function elucidation and high-throughput screening of drug discovery compounds. A variety of cell-free expression systems exist with different strengths. Selection of a precise cell-free application systems depends on research goals and needs.
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