Precision Medicine- An Emerging Approach for Prevention & Treatment of Diseases

Various diseases currently do not possess proven treatments or preventions. For making a difference for millions of people suffering from these diseases, it is crucial to gain better insights in environmental, behavioral and biological factors driving these diseases. Precision medicine is an upcoming approach for treatment and prevention of disease taking into account individual variability in lifestyle, environment and genes for every individual. The global precision medicine market is projected to register around 14% CAGR during 2016 to 2024 according to a study by Persistence Market Research (PMR).

Factors Propelling the Growth of Global Precision Medicine Market Include

  • Growing approval of drugs as well as their companion diagnostic assays
  • Effective DNA profiling
  • Increasing incidences of cancer diseases
  • Growth of data-driven healthcare
  • Soaring utilization of ‘multi-omics’ for research tied with high throughput sequencing platform penetration
  • Exponential growth in number of targeted molecules within pipeline for specific application

The elevating price of drug discovery with rising regulatory requirements has necessitated the rise in demand for an individualized product. Companion diagnostics development has resulted in provision of relevant clinical & biological information as well as a set of tools for addressing several pharmaceutical companies. Leading players are concentrating on patenting a molecule with its companion diagnostics for achieving a profit margin, competitive edge and more usage. Owing to availability of companion diagnostics, both physicians and patients assured of the effectiveness of therapy.

The All of US Research Program

As a part of federal precision medicine initiative, the National Institutes of Health (NIH) is making an effort in building a large-scale, national research enterprise with over one million volunteers for extending precision medicine to almost all diseases. The All of US Research Program, named as PMI Cohort Program formerly, will be a data-driven, participant-engaged enterprise to support research at intersection of genetics, lifestyle and environment for producing new knowledge along with the development of more effective ways for prolonging health & treatment of disease. More importantly, the program will not only concentrate on disease but also on the ways to increase the chances of an individual to remain healthy throughout life. According to an information from the Advisory Committee’s working group to the director of NIH, the All of US Research Program has commenced building infrastructure & capacity owing to several funding awards and will be recruiting participants during this year.

For Precision Medicine to Become Reality, Five Key Challenges are Expected to be Faced which Include

  • Clinical Trials– It must be easier for accomplishing clinical trials and genomic testing must be more affordable for creation of more specific treatments.
  • Data– In a future perspective, data is likely to be the most sizeable challenge considering the process of data collection. Moreover, many issues are faced in the integration of data into EHR workflow. It is necessary for the healthcare industry to find ways for building upon this data for making better care decisions.
  • Empowering Patients– Healthcare organisations are focusing on ways to figure out the role of patients in precision medicine. In addition, few organizations have been working on patient policies.
  • Support of Physicians– Healthcare leaders should ensure than physicians possess the time, confidence and education in handling precision medicine, at the same time reducing the care gaps for appropriate precision medicine practice.
  • Construction of a Case for Precision Medicine– Several insurers possess rigorous guidelines for figuring out what will be covered. It is necessary to demonstrate precision medicine’s support to the organization’s overall goals.

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Global Multiplex Immunoassay Market to Witness Significant Growth Owing to its Widespread Applications

A multiplex immunoassay is a type of assay capable of simultaneously measuring multiple analytes in a single cycle of the assay. These are widely utilized in experiments of functional genomics seeking detection of state of all biomolecules of given class in a biological sample. The developments in multiplex immunoassays is attributed to increasing requirement for enhanced procedures of disease analytics along with minimized errors and diminished costs. The possibility of multiplex immunoassays of providing quantitative information via parallel examinations is a promising development. The global multiplex detection immunoassay market is projected to witness 7.5% CAGR during 2016 to 2024, according to a study by Persistence Market Research (PMR).

Growing Geriatric Population and Healthcare Infrastructure to Boost the Growth of Multiplex Immunoassay Market

Growing geriatric population inclined to chronic infections and immune system sickness is expected to propel the growth of global multiplex detection immunoassay market. The prominence of multiplex assay in purpose of care or clinical diagnostic is attributed to its capacity to produce reportable outcomes through a single specimen. Owing to soaring government expenditure in medical improvement and clinical diagnostics as well as robust growth of healthcare infrastructure, the global multiplex detection immunoassay market is expected to register a significant development in the near future. In addition, rapid growth of medical technologies and cost-effective treatment among regions of Latin America and Asia Pacific are some other prominent factors driving the overall market.

Impeding Factors for Growth of Multiplex Immunoassay Market

However factors such as stringent administrative endorsements and lack of reimbursement policies are expected to confine the development of multiplex immunoassays. Improvement of multiplexed immunoassays involve thorough assay configuration approval and systematic execution for minimizing inaccuracy and test imprecision. Challenges associated with multiplex immunoassays setup incorporate determination & immobilization of alignment, capture ligands, impedance in proteins and antibodies. Owing to financial drawbacks of some countries in adoption of new technology, the growth of global multiplex detection immunoassay market is expected to be restricted.

Opportunity Created for Researchers Owing to Emergence of Multiplex Immunoassays

For more than five decades, immunoassays have helped researchers in the identification and monitoring of protein expression by using an antibody that specifically targets the protein of interest and a report or label that is measured. Immunoassay’s application was once limited to basic research but they have extended into clinical-research and diagnostic spaces. Owing to emergence of multiplex immunoassays, an opportunity has been created for researchers to access excess information on a series of protein in a single reaction of an experiment.

Multiplex immunoassays not only help in gathering more information in short time but also conserve expensive, precious and/or significantly small volume samples. Researchers are adopting to rising number of available multiplex immunoassay tools for investigation of cellular regulatory events occurring in cancer. Pharmaceutical industries are adopting to multiplex immunoassays for increasing their testing power.

Bio-Rad’s Bio-Plex Pro Mouse Chemokine Panel

Many companies have come up with various technologies in the global multiplex detection immunoassay market. Bio-Rad Laboratories, Inc. recently made an announcement of introducing its “Bio-Plex Pro Mouse Chemokine Panel”, the latest in its array of magnetic bead-based multiplex immunoassays. This panel is capable of detecting more panel as compared to any other available assay, permitting researchers for harnessing more data with each run. The Bio-Rad’s Bio-Plex Pro Mouse Chemokine Panel provides highest sample detectability with actionable and clear results.

Benefits of Bio-Plex Pro Mouse Chemokine Panel Include

  • High Sensitivity & High Signal-to-Noise Ratio– provides improved sample detectability with the help of optimized reagents to offer a broad dynamic range
  • Wide Coverage of Panel– detects a large number of biologically relevant targets in single well.
  • Ready to Use (Premixed) Reagents– streamlines workflow with a simplified protocol and premixed reagents

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Cell-Free Protein Expression Market to Progress Owing to Approaches & Development of Protein Production Methods

The global market for cell-free protein expression is anticipated to register 6% CAGR during 2016 to 2024 and reach a market value of US $268.4 million by 2024 end according to a study by Persistence Market Research (PMR). The future landscape of global cell-free protein expression market will be defined by novel approaches & development of cost-effective, fast and reliable methods for proteins production on an industrial scale. Factors such as increasing R&D outsourcing by biotechnological and pharmaceutical companies, sales drop of patent cliff resulting into increasing research intensity in pharmaceutical sector, declining R&D productivity and increasing bio-similar development expenditure are expected to drive the global cell-free protein expression market.

Establishment of Precipitating & Soluble Membrane Fragment Methods by Study of Mammalian Membrane Protein Production

Cell-free protein expression basically is the process of recombinant proteins production in cell lysates instead of cultured cells. Cell-free protein expression methods are expected to come forth as the standard procedures for oriented membrane protein preparation- crystallography, since they tackle ceaseless problems associated with cell-based recombinant expression methods pertaining to mammalian membrane proteins preparation. As per Scientific Reports 6, Article 30442, solution to four membrane proteins’ crystal structures, from unicellular alga or bacteria, has been obtained through samples prepared by cell-free protein synthesis.

This study on mammalian membrane protein production establishes the soluble and precipitating membrane fragment methods in which synthesis of membrane proteins takes course through Escherichia coli cell-free system including small & large membrane fragments with simultaneous integration of these fragments into lipid environments. Various mammalian membrane proteins such as γ-secretase subunits, human claudins and glucosylceramide synthase can be produced by applying precipitating membrane fragment method. While, substantial membrane proteins cab be produced by applying soluble membrane fragment method. As per this study, obtaining high quality crystals of complex human claudin-4 was successful by using enterotoxin.

Profacgen’s Announcement of Advancing its Facilities & Platforms for Thorough Feasibility Analysis

Profacgen, a New York-based biotech company, recently made an announcement about its plans on advancing its platforms & facilities in order to perform a thorough feasibility analysis prior to the initiation of every protein expression project deployed by it. Profacgen significantly focuses on cell-free expression & animal-free expression. Recombinant protein expression’s key success depends upon the appropriate protein expression system choice. Several factors must be considered including intended application, target protein property, cost and protein yield while choosing the system.

A comprehensive expression systems portfolio is provided by Profacgen’s services of custom recombinant proteins. System that are often used by Profacgen’s customers include yeast expression, bacteria expression, mammalian expression and insect/baculovirus expression. World-class protein biologists of Profacgen have extensive experience in the field of protein expression. Profacgen commits to provide more customer-friendly services by advancing their technology to these services.

Invenra Raises $3 Million for Antibodies Development

WI-based Invenra’s cell-free protein expression technology allows screening of thousands of full antibodies at a much faster rate than conventional cell-based methods used for searching therapeutic antibodies. Last year, Invenra announced raising $3 million for development of antibodies with and for drug makers. Some of this money, according to Mark Kubik, Invenra’s vice president for business development, will be applied for fulfilling its agreements made with drug companies which includes U.K.-based Oxford BioTherapeutics.

Cell-free protein expression is a convenient method for small amounts of protein generation used for several applications such as protein-nucleic acid interactions, protein-protein interactions, functional assays, toxicity screening and structural analysis. Providing quick and easy access to proteins of interest, cell-free protein expression remains stapled to collection of tools available for understanding cellular pathways & mechanisms, protein structure & function elucidation and high-throughput screening of drug discovery compounds. A variety of cell-free expression systems exist with different strengths. Selection of a precise cell-free application systems depends on research goals and needs.

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Global Tea Market to Gain Traction in the Near Future Owing to Health Benefits and Product Innovations

A cup of tea comes with various health benefits. Globalization has considerably set in motion in the recent past. Tea industry is likely to have impacted significantly owing to the ever-elusive globalization. Tea has even been witnessed to replace coffee as primary source of caffeine & energy for consumers. Tea consumers are a fan of its taste and quality, seeking new & unique variety in tea products. Consumers look forth for luring flavors and blends in tea products such as mint flavor, lemon flavor, chocolate flavor, fruit flavor, etc. A study by Persistence Market Research (PMR) states that more than 500 tea varieties are available worldwide. Tea lounge, in order to attract consumers, are offering broad varieties of tea along with various blends, flavors and colors leading to drive the global tea market growth in the near future.

Rising consumer awareness on health & wellness, and percolating psychological necessity of people for human interaction is providing support to tea-specific retail outlets across the globe. Hence, rising tea café & lounge culture penetration, particularly in Asia Pacific and American countries, is leaning towards the growth of global tea market. The global tea market is projected to witness 5% CAGR during 2016 to 2024 to reach a market value of US $21.33 billion by 2024 end, as per PMR’s report.

Nestle Waters’ New Line of Tea Products

Stamford-based firm, Nestle Waters, is spilling out new lines of brewed & fruit-flavored Nestea products within the United States. The revamped fruit-flavored lines comprise peach, lemon and raspberry varieties. The fruit-tinged offerings in this new real-brewed tea line prepared by hot-fill brewing include slightly sweet black tea, unsweetened black tea, slightly sweet organic green tea and rooibos (red tea). Except unsweetened black tea with zero calorie, calorie counts of new products are relatively comparable to their predecessors. Nestle Waters concentrated on Nilgiris district in southern India for production of all of its tea.

Benefits from Green Tea

Owing to its health benefits, green tea consumption has become a trend worldwide. It consists of bioactive compounds such as flavonoids and catechins (both powerful antioxidants) that aid in health improvement. EGCG or epigallocatchin-3-gallate is the most potent compound present in green tea used for treatment of various diseases. Green tea helps in improving concentration and focus as it contains caffeine. The presence of some antioxidants in green tea is observed to lower cancer risk. Green tea improves short-term memory, especially it helps in protection of brain against neurodegenerative disorders such as Parkinson’s and Alzheimer’s disease which are most probably developed in old age. Catechins can kill bacteria and viruses lowering risk of developing infections. Drastically increasing blood’s antioxidant capability, green tea prevents oxidation of LDL cholesterol particles reducing the risk of cardiovascular disease. Green tea has been observed to reduce blood-sugar levels and improve insulin sensitivity which in turn results into lower risk for type 2 diabetes.

Flexible Vegetable Fabric Derived from Tea

Pursuing help from a biologist, Suzanne Lee – a British researcher, developed a new material production method known as BioCouture that utilizes bacteria for growing a fabric. The procedure includes simple steps – brewing 30 liters of tea and adding few kilos of sugar when the brew is hot. Living organism is then poured into the mixture with acetic acid. The whole mixture is then dried carefully as most of its constituent is water and with proper thermoregulation a thick layer of fabric is formed. It is a light-weight paper-like layer and Lee calls it ‘flexible vegetable leather’. No waste residues are left post process and this fabric can be decomposed when necessary. Lee’s research gained huge traction among industries and spread inspiration.

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Global Medical Implants Sterile Packaging Market to Gain Traction Owing to Implementation of ISO 11607

Prevention of medical implants from any kind of contamination with the help of packaging is known as sterile packaging. Sterilization process involves utilization of various technologies for destroying microorganisms such as viruses, prions & other transmission agents. Owing to the implementation of ISO 11607 across medical devices and pharmaceutical industries, medical implants sterile packaging concept gained traction over the previous two decades. The global medical implants sterile packaging market is projected to witness an impressive 6.5% CAGR during 2016 to 2024 according to the report by Persistence Market Research (PMR).

Key factors influencing the growth of global medical implants sterile packaging market include

  • Growth in chronic degenerative diseases
  • Regulatory compliances pertaining to medical device packaging sterilization
  • Increasing hygiene and healthcare expenditure
  • Increasing demand for sterilization in product implants such as knee implants, joint implants, breast implants, hand/foot replacement and dental implants

FlexShield to Suit Wide Range of Medical Devices & Implants Owing to its Puncture-Resistant & Abrasion-Resistant Properties

Recent expansion of FlexShield product line by UFP Technologies includes sterile barrier integrity protection of most of the medical devices. UFP, a custom-engineered components producer, serves the automotive, defense, consumer, medical, aerospace, electronics and industrial markets. FlexShield production involves use of medical-grade biocompatible TPU (thermoplastic polyurethane) films certified by UFP Class VI and FDA approved. FlexShield got introduced in 2013 and designed later into several packaging & component configurations catering to the requirements of global orthopedic implant & medical device companies. A wide range of medical devices & implants such as hip stems, trocars, fixation plates, surgical saw blades and surgical screws are best suited by the abrasion-resistant and puncture-resistant FlexShield.

FlexShield may be Formed According to Accommodation Requirements of Devices

Formation of FlexShield may be altered based on accommodation of devices. At present FlexShield products available in the market include tip protectors for delicate & sharp medical instruments, bags ensuring sterile barrier integrity with an extra protection layer and ergonomically designed pouches allowing easy access to medical devices by medical personnel. The material of FlexShield has been approved for skin contact and used for protection of patients from infection at the time of surgery and safeguarding sensitive medical equipment. Currently, applications of FlexShield Include

  • Surgical aids for prevention of infection
  • Sterile barrier integrity protection for medical equipment
  • Orthopedic Implant Sleeves
  • Robotic components

Barger Asked to Develop a Single Packaging System Capable of Packing Polished as well as Abrasive Components

Universal Packaging, with its award-winning recent design for total hip replacement system, is a continuing trend in the field of orthopedic implant packaging. A double sterile barrier system designed & manufactured by Barger was entitled with Gold award recently at the time of annual thermoforming parts competition of SPE (Society of Plastic Engineers). Barger was requested to develop single packaging system capable of accommodating as many various components as possible along with protection in order as one of the components was highly polished with a mirror finish and another component consisted of rough surface capable of damaging a sterile barrier. All packaging components required to be compatible with gamma and EtO (ethylene oxide) radiations.

Barger Product with Double Sterile Barrier Produced from BargerGard TPU

Barger derived a product as per the requirements which comprised of inner & outer thin-gauge PETG trays with interchangeable protective inserts produced from BargerGard TPU (theromoformed polyurethane). This guaranteed protection of both polished as well as abrasive components. There are several benefits to Barger’s product such as less capital requirement for sealing and tooling equipment, constant and impressive experience provided with every package, fewer validations, same shelf space occupied by products and a lower overall cost.

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